Life sciences and molecular diagnostics companies worldwide are switching to lyophilization.
Argonaut is the leader in

Lyophilization Services

Why Lyophilized Beads are the Next Big Thing
The World's Smallest Lyophilized Reagents
Introducing BioFuse™ Sample Prep
Simplify Your
Molecular Assays

Why Lyophilization?

Lyophilization Technologies is a dehydration process that takes place after a product has been frozen. Lyophilization is popular in life sciences because lyophilized reagents and assays have many benefits including ease of use and reduced total cost. Lyophilized reagents ship at ambient temperature, reduce storage and shipping costs. Lyophilized products also have a longer shelf life, leading to less waste. 

benefits of lyophilizED ASSAYS & REAGENTS

Lyophilized products use less warehouse space, lower electrical and equipment costs, and reduc environmental impact. Ambient shipping is more flexible and less risky in todays complex shipping environment.

Shipments, even with critical enzymes, can be bumped off flights due to weight and dry ice. Lyophilization eliminates risk of temperature variations. No more dry ice delays. Prevent excess and obsolete inventory.

Lyophilized reagents, enzymes, beads and antibodies have been shown to be stable for years in lyophilized format. Stab-tests show antibodies >20 years old that perform like the day they were lyophilized.

Lyophilization eliminates difficult small-volume pipetting steps. Reduce user errors with simpler protocols.

Cold chain shipping adds 40x shipping material weight for domestic and 80x weight for international, compared with ambient shipping with lyophilized products! Lyophilization eliminates styrofoam coolers and dry ice. Your product ships in recyclable containers, and boosts environmental goals and regulatory compliance.

Argonaut is the exclusive producer of LyoDose beads, a proprietary spherical lyophilized bead format that contains a specified volume of reagent.

Lyophilization reduces costs and eliminates cold chain logistics

Curious to See LyoDots™ and BioFuse™ Reagent Mixer in Action?

3-Phase Argonaut Lyophilization Platform

Why Lyophilize With Argonaut?

Setting up an in-house lyophilization facility requires significant investment of time and resources. Accelerate your project at a lower cost. Working with our full-service infrastructure, your project has access to:

Proprietary lyophilization technology

  • Decades of expertise in lyophilized assays, reagents, buffers, nucleotides, compounds, proteins & PCR kits.
  • ISO 8, relative humidity-controlled clean dry rooms for lyophilization and packaging activity.
  • FDA cGMP compliance & ISO 13485:2016
  • Custom packaging
  • Global distribution & storage
  • Ability to quickly scale production
The lyophilization
center of excellence

was established because development and production of lyophilized assays & reagents requires specialized expertise. Argonaut’s team can take you from liquid reagents to a fully lyophilized assay within weeks, reducing your time to market. We ensure you have the solution best matched to your goals. Click to see if Lyo is a good match!

Lyophilization is suited for small to large scale projects, for Life Sciences and Applied Markets to high-scale commercial products, and highly regulated clinical IVD products.


Download whitepaper comparing the costs of lyophilized reagents vs. wet reagents using Total Landed Cost analysis.

Lyophilization Reveals

Hidden Costs of Cold-Chain Logistics


Many Life Science and Molecular Diagnostics companies are switching their products to a lyophilized format. But that doesn’t mean it’s the ideal match for every application.

Argonaut leads lyophilization technology but we want to ensure you have the solution best matched to your goals.

Ambient or Cold Chain? 2 minute survey will give you the answer

Frequently Asked Questions (FAQs)

About Lyophilization Services

A: Lyophilization is also known as freeze drying. It is a dehydration process that takes place after a product has been frozen. Lyophilization is gaining popularity in the life sciences for reagents and assays due to its numerous benefits, including extended shelf-life and ease-of-use.

A. Argonaut offers a wide range of reagent lyophilization services options. Our most popular format is LyoDose™ beads, although in situ, vials, and swabs are also common. Drug products are not able to be lyophilized at this time.

A: Argonaut is the exclusive supplier of LyoDose™ beads, which are unit-dose lyophilized spheres. LyoDose™ beads offer significant advantages including faster reconstitution time, improved user experience, and reduced contamination risk.

A: Unfortunately we do not offer pharmaceutical lyophilization services at this time. Please refer to our drug products manufacturing page for our full biopharma capabilities.

A: With a few exceptions, most liquid reagents can be lyophilized. Examples of projects include qPCR reagents, NGS kit components, and molecular diagnostics cartridges.

A: Lyophilization requires careful optimization of parameters. Our lyophilization feasibility program determines the best manufacturing process for your product, prior to full-scale production. The feasibility study produces small batches of lyophilized product with three different excipients (inert components that stabilize products during the lyophilization process), which are then tested. This facilitates selection of the best excipient for optimal lyophilization.

A: Yes, your product can be produced to cGMP compliance. Argonaut offers full cGMP manufacturing capabilities, and our lyophilization equipment is housed within our ISO manufacturing suites.

A: Lyophilization offers many advantages, including cost savings, improved user experience, and environmental responsibility.

A. At production scale, units can be produced inexpensively in the same lyophilizer run. The initial investment in lyophilization services is quickly repaid with reduced cold chain expenses, fewer user errors, and longer expiration windows.

A. Turnaround times on lyophilization are usually quick, often 1-2 weeks. If you plan to manufacture under cGMP please allow time for documentation and technology transfer.

Formulations containing high levels of glycerol or salt are difficult to lyophilize. Click the link below to contact us and we can provide suggestions tailored to your specific reagents.

A. Lyophilization is a complex process that requires extensive optimization. Argonaut has decades of experience in setting these parameters and selecting excipients. As a result, our lyophilization feasibility program has a high success rate in achieving a suitable product.

You're in Control

Frozen vs. Ambient

Which reagent delivery method do you prefer? We offer a wide range of reagent lyophilization services options.

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